Carcinogens Program

Definition:

A carcinogen is a substance or agent capable of causing cancer. They are chronic toxicants with long latency periods that can increase the risk of certain forms of cancer after repeated or prolonged exposures; however, they often do not have immediately noticeable health effects.

Regulation:

The California Occupational Safety and Health Administration (Cal/OSHA) §5209 (and other sections) requires that no worker be exposed to carcinogen concentrations above established limits.

Resources:

Anyone working with carcinogens must also review the following:

Carcinogen Safety: Quick Guide for PIs and Lab Supervisors

Carcinogen Training -Mandatory each year for all carcinogen users

Chemical Hygiene Plan

Control Banded Standard Operating Procedures

For additional information go to: Known and Probable Human Carcinogens as described by the American Cancer Society.

Guidelines:

Prior to working with any carcinogens, please consult with your EH&S Department Safety Advisor (DSA) or the UCSF Chemical Hygiene Officer to assess your level of exposure.

All carcinogens are regulated by Cal/OSHA and categorized under the three main categories listed below:

Listed – Listed are the most hazardous and more restrictive class of carcinogens. Cal/OSHA has established extensive regulations governing their distribution, handling, and use. Any handling or use of the 13 “listed” carcinogens below requires evaluation by EH&S before the material is ordered and reporting to Cal/OSHA.

2-Acetylaminofluorene

4-Nitrobiphenyl

4-Aminodiphenyl

N-Nitrosodimethylamine

Benzidine and its salts

beta-Propiolactone

3,3’-Dichlorobenzidine and its salts

bis-Chloromethyl Ether

4-Dimethylaminoazobenzene

Methyl Chloromethyl Ether

alpha-Naphthylamine

Ethyleneimine

beta-Naphthylamine

 

Regulated –The requirements are triggered by the level of exposure, which can vary from one person to another. “Regulated carcinogens” is an extensive list, some examples include: Methylene Chloride, Benzene, and Formaldehyde. All carcinogens must be accompanied with a Standard Operating Procedure (SOP) and proper training provided or arranged by the Principal Investigator (PI).

Select – Select carcinogens are defined as “known to be carcinogenic” by the National Toxicology Program and categorized using the Globally Harmonized System (GHS) listed below. GHS is a worldwide initiative to promote standard criteria for classifying chemicals according to their health, physical hazard, and environmental hazard.

Group 1: Carcinogenic to humans
Group 2A: Probably carcinogenic to humans
Group 2B: Possibly carcinogenic to humans

Carcinogen Use in Rodents

Researchers using any of the following chemicals must follow the SOP on “Particularly Hazardous Chemicals (PHC) in Rodents.”  Special handling procedures apply to these animals and their cages and bedding.

 

For questions regarding carcinogens at UCSF, please contact the Chemical Hygiene Officer at EH&S: (415) 476-1300