Recombinant DNA Exposure Protocol

Organism or Agent:

Recombinant DNA

Exposure Risk: Mutagenesis/Oncogenesis/Transgene Expression
UCSF Occupation Health: 415-885-7580 (work hours, 8am to 5pm)
Exposure Hotline Pager: 415-353-7842 (24 hours)
Office of Environment, Health & Safety: 415-476-1300 (work hours)
UCSF Police Department; 415-476-1414 or 9-911 (In case of emergency, 24 hours)
EH&S Public Health Officer:
415-514-3531 (work hours)
Student Health Services: 415-476-1281 (work hours)
Biosafety Officer 415-514-2824 (work hours)

Occ Hlth Proto Button
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In the event of an accidental exposure or injury, the protocol is as follows:

1. Potential Modes of Transmission:

  • Skin puncture or injection
  • Ingestion
  • Contact with mucous membranes (eyes, nose, mouth)
  • Contact with non-intact skin
  • Bite from a recently infected animal
  • Percutaneous contact with body fluids from a recently infected animal
  • Aerosols
  • Other

2. First Aid:

  • Skin Exposure, immediately go to the sink and thoroughly wash the wound with soap and water. Decontaminate any exposed skin surfaces with an antiseptic scrub solution.
  • Skin Wound, immediately go to the sink and thoroughly wash the wound with soap and water and pat dry.
  • Splash to Eye(s), Nose or Mouth, immediately flush the area with running water for at least 10 minutes.
  • Splash Affecting Garments, remove garments that may have become soiled or contaminated and place them in a double red plastic bag.

3. Emergency Treatment:

  • In the event of an acute injury resulting from a laboratory incident which requires immediate medical care, the injured employee should report to the emergency room for acute medical treatment. The injured employee must take a copy of this document to the emergency department as well as the “Viral Vector Exposure Risk Assessment Part 1” if applicable. 
  • In the event of an exposure, with or without an injury, call the Exposure Hotline pager in order to get access to medical care for the exposure.

4. Follow-up is needed in the event of any Laboratory Exposure: 

  • After first-aid is complete, immediately inform you supervisor of the exposure.
  • In the event of a large spill, contact the emergency response team (9-911) for clean-up.
  • Contact Occupational Health Services for employees (in case of a student exposure, Student Health Services), after first aid is complete for follow-up care.

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Roles and responsibilities after an accidental exposure:

1.  EMPLOYEE’S RESPONSIBILITIES (Worker Initial Self-Care)

  • First Aid: Perform the recommended first aid and decontamination according to the posted instructions.
  • Treatment: i) In the event of an acute injury resulting from a laboratory incident which requires immediate medical care, the injured employee should report to the emergency room for acute medical treatment. The employee should bring a copy of the “Viral Vector Risk Assessment Summary Part 1” if applicable as well as this document for review. ii) In the event of an exposure, with or without an injury, call the Needlestick Exposure Hotline pager in order to get access to medical care for the exposure.
  • Access to Exposure Hotline: Call the Exposure Hotline pager in order to get access to medical care for the exposure. Dial 415-353-7842.
  • Reporting: Inform your laboratory supervisor / principal investigator of the exposure.
  • Secure the laboratory: Identify the equipment involved in the exposure and the mechanism of exposure. Make sure that the laboratory area has been secured and that notification of contamination has been posted to prevent other individuals from entering the area. 
  • Follow up: Contact Occupational Health Services (OHS) as soon as possible for any follow up care if needed. Call the main line at 415 / 885-7580.

2. SUPERVISOR’S RESPONSIBILITIES 

  • First Aid and Decontamination: Verify that the worker has washed and decontaminated himself/herself.
  • Secure the laboratory: Confirm that the laboratory area has been secured and that notification of contamination has been posted to prevent other individuals from entering the area.
  • Laboratory clean-up (as needed): Contact the Office of Environment Health & Safety (EH&S) through the UC Police Department Emergency Dispatch (from a campus telephone 9-911, from a non-campus phone 415/476-1414).
  • Report the exposure: Call OHS or SHS during regular hours. Briefly describe the circumstances of exposure. Provide employee identification information (name and home telephone number).
  • Follow – Up: Confirm that the employee has called for an appointment at the UCSF Occupational Health Clinic for evaluation on the next weekday the clinic is open (In case of a student exposure, confirm that the student has called Student Health Services). Later, confirm that the employee has been evaluated and coordinate a safe return to work.
  • Report the Injury: Within 24 hours, report the injury to the UCSF Human Resources Disability Management Services (HR DMS) Office on the Supervisor’s Report of Injury (SRI) form.
    http://ucsfhr.ucsf.edu/files/SIR.pdf